Before Treatment

An estimated 0.7% to 3% of the world population may experience an allergic reaction to collagen of animal origin; results show that sensitization to Salvecoll® occurs in less than 0.7% of patients. Patients without history of hypersensitivity to Salvecoll® did not develop allergic reactions after subsequent repeated injections or implantation of the product.

Salvecoll® should not be used in the following cases:

  • Development of a positive reaction to the skin test
  • Existence of an autoimmune disorder (a disease arising out of or affecting the tissues), including rheumatoid arthritis, systemic lupus erythematosus, scleroderma, Sjogren’s syndrome and dermatomyositis / polymyositis.
  • The presence of tumors in close proximity to area of intervention.
  • Ongoing treatments such as chemotherapy, radiotherapy or immunosuppression

The use of Salvecoll® in combination with a synthetic filler is not recommended due to the possible increased risk of infection and topical inflammation. Occasionally migration of implanted materials can also be observed.

Use of Salvecoll® with other medicines

  • Because Salvecoll® has properties allowing it to form complexes with various active pharmacological substances (anti-inflammatory, antibacterial, antiviral, etc.), Salvecoll® can be used as a carrier for the transport of these substances with the added possibility of creating a barrier against the penetration of bacteria.
  • Salvecoll® gel is not recommended for use while taking anticoagulants, antiplatelet agents, isotretinoin (Roaccutane), nonspecific anti-inflammatory drugs for external use, enzyme preparations.
  • Salvecoll® gel may be introduced with antibacterial and antiseptic preparations.

Pregnancy and lactation

Application of Salvecoll® during pregnancy and lactation has not been studied